ZAP70 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A2195-20, A2195-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 70kDa
Observed Molecular Weight: 70kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 7535
SWISS: P43403
Alternate Names: SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70; ZAP70
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Protein phosphorylation, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Immunology Inflammation, T Cell Receptor Signaling Pathway.
NCBI Alias: ZAP70
Research Use Only