1A68 rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES18548-50, ES18548-100
Citations, Manuals and MSDS Available upon request.
Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans
Source: Rabbit
Applications: WB
Dilution: WB 1: 500-2000
Reactivity: Human; Rat; Mouse;
Immunogen: Synthesized peptide derived from human 1A68 AA range: 1-51
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human SWISS Prot NO: P01891
Subcellular Location: Golgi membrane, endoplasmic reticulum, Golgi apparatusGolgi medial cisterna, plasma membrane, integral component of plasma membrane, cell surface, ER to Golgi transport vesicle membrane, membrane, integral component of membrane,
Research Use Only