3HAO Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP08399-20, BT-AP08399-50, BT-AP08399-100
Citations, Manuals and MSDS Available upon request.
Background: 3-Hydroxyanthranilate 3|4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs| such as liver and kidney| and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Research Areas: Metabolism; Neuroscience; Signal transduction
Target Protein: HAAO
Applications: WB, ELISA
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: 3-hydroxyanthranilate 3|4-dioxygenase
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: P46952; Mouse: Q78JT3; Rat: P46953
Synonyms: 3-hydroxyanthranilate 3; 4-dioxygenase (EC 1.13.11.6;3-hydroxyanthranilate oxygenase;3-HAO;3-hydroxyanthranilic acid dioxygenase;HAD)
GeneID: Human: 23498
Research Use Only