4E-BP1 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Number: BT-MCA0093-50, BT-MCA0093-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Research Areas: Epigenetics and nuclear signaling; Metabolism
Target Protein: EIF4EBP1
Applications: WB, ELISA
Reactivity: Human
Clonality: Monoclonal
Host: Mouse
Isotype: IgG
Full Product Name: Eukaryotic translation initiation factor 4E-binding protein 1
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
UniProt Accession: Human: Q13541; Mouse: Q60876
Synonyms: EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
GeneID: Human: 1978
Research Use Only