4E-BP1 Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Number: BT-MCA4374-50, BT-MCA4374-100
Citations, Manuals and MSDS Available upon request.
Background: 4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Research Areas: Others
Target Protein: 4E-BP1
Applications: IHC
Reactivity: Human
Clonality: Monoclonal
Clone ID: 11G12C11
Host: Mouse
Isotype: Mouse IgG1
Full Product Name: 4E-BP1
Immunogen: Purified recombinant fragment of 4EBP1 expressed in E. Coli.
Storage: 4°C|-20°C for long term storage
Formulation: Ascitic fluid containing 0.03% sodium azide.
UniProt Accession: Q13541
Synonyms: BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, EIF4EBP1
GeneID: 1978
Research Use Only