8ODP rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES9331-50, ES9331-100
Citations, Manuals and MSDS Available upon request.
Background: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer is
Source: Rabbit
Applications: WB; ELISA
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Reactivity: Human; Rat; Mouse;
Immunogen: Synthesized peptide derived from human protein . at AA range: 1-80
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 21kD
Human Gene ID: 4521
Human SWISS Prot NO: P36639
Subcellular Location: [Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus. Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328).; [Isoform p26]: Mitochondrion matrix.
Research Use Only