a-actinin (4A12) Mouse mAb
Sizes: 50μL, 100μL
Catalogue Numbers: EM1261-50, EM1261-100
Citations, Manuals and MSDS Available upon request.
Background: α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.
Alternate Name: actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody
Source: Mouse
Applications: IHC
Dilution: IHC 1:100-200
Reactivity: Human, Rat, Mouse
Immunogen: Recombinant Protein
Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed Band (KD): 103kDa
Human Gene ID: 87
Human SWISS Prot NO: P12814
Subcellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane
Research Use Only