A1Up rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES6860-50, ES6860-100
Citations, Manuals and MSDS Available upon request.
Background: PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 UBA domain., similarity:Contains 1 ubiquitin-like domain., subcellular location:May associate with the endoplasmic reticulum., subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum., tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.,
Alternate Name: UBQLN4; C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75
Source: Rabbit
Applications: WB; IHC; IF; ELISA
Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Reactivity: Human; Mouse
Immunogen: The antiserum was produced against synthesized peptide derived from human UBQLN4. AA range:201-250
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 54kD
Human Gene ID: 56893
Human SWISS Prot NO: Q9NRR5
Subcellular Location: Nucleus. Cytoplasm. Chromosome. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738).
Research Use Only