AAK1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A22105-20, A22105-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
GeneID: 22848
Swiss Prot: Q92583
Tested Applications: ELISA, WB
Reactivity: Human
Calculated Molecular Weight: 11kDa
Observed Molecular Weight: 104kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 450-550 of human AAK1 (NP_055726.4).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, Kinase
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa
Cellular Location: Extra Cellular Region, Extra Cellular Space
Symbol: AAK1
Category: Polyclonal Antibodies
Research Use Only