AANAT Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-10969-60, E-AB-10969-120, E-AB-10969-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: AANAT
Target Synonym: AA-NAT; Aanat; Aralkylamine N-acetyltransferase; Arylalkylamine N acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT; SNAT
Research Areas: Cancer, Metabolism, Neuroscience
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q16613
Background: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Concentration: 0.6 mg/mL
Immunogen: Recombinant protein of human AANAT
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only