ABCA4 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA30940-50, RA30940-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: WB 1:500-2000 ELISA 1:5000-20000
Background: ATP binding cassette subfamily A member 4 (ABCA4) Homo sapiens The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse
Molecular Weight: 250
GeneID (Human): 24
Protein MW (KDa): 250
SWISS: P78363
Source: Rabbit
Research Use Only