Ack1 Rabbit Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA36736-50, RA36736-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, and 0.44% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: WB 1:500-2000
Alternative Names: Activated CDC42 kinase 1 (ACK-1) (EC 2. 7. 10. 2) (EC 2. 7. 11. 1) (Tyrosine kinase non-receptor protein 2)
Background: tyrosine kinase non receptor 2 (TNK2) Homo sapiens This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],
Applications: WB
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 10188
SWISS: Q07912
Source: Rabbit
Research Use Only