Acrogranin Rabbit Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA21617-50, RA21617-100
Citations, Manuals and MSDS Available upon request.
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Store At/In: -20°C/1 year
Recommended Dilutions: WB 1:1000-2000 ELISA 1:5000-20000
Alternative Names: Granulins (Proepithelin; PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G) ; Granulin-2 (Granulin F) ; Granulin-3 (Granulin B) ; Granulin-4 (Granulin A) ; Granulin-5 (Granulin C) ; Granulin-6 (Granulin D) ; Granulin-7 (Granulin E) ]
Background: disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. ,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. ,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. ,PTM:Granulins are disulfide bridged. ,similarity:Belongs to the granulin family. ,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. ,
Applications: WB; ELISA
Species Cross-Reactivity: Human; Rat; Mouse;
GeneID (Human): 2896
SWISS: P28799
Source: Rabbit
Research Use Only