ALDH18A1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A12247-20, A12247-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
Synonyms: GSAS; P5CS; PYCS; SPG9; ADCL3; SPG9A; SPG9B; ARCL3A; ALDH18A1
GeneID: 5832
Swiss Prot: P54886
Tested Applications: ELISA, WB
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 87kDa
Observed Molecular Weight: 87kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Epigenetics Nuclear Signaling, RNA Binding, Cancer, Signal Transduction, Endocrine Metabolism, Amino acid metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: U-87MG, Mouse testis, Rat brain
Cellular Location: Mitochondrion Inner Membrane,
Keywords: 5832, sc-104810, ALDH18A1, GK, GPR, GSAS, P5CS, PYCS, ADCL3, ARCL3A, SPG9, SPG9A, SPG9B, aldehyde dehydrogenase 18 family member A1, delta-1-pyrroline-5-carboxylate synthase, aldehyde dehydrogenase family 18 member A1, delta-1-pyrroline-5-carboxylate synthetase, delta1-pyrroline-5-carboxlate synthetase, pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase), spastic paraplegia 9 (autosomal dominant), P54886, Aldehyde Dehydrogenase 18 Family Member A1, Pyrroline-5-Carboxylate Synthetase (Glutamate Gamma-Semialdehyde Synthetase), Aldehyde Dehydrogenase Family 18 Member A1, Spastic Paraplegia 9 (Autosomal Dominant), Spastic Paraplegia-9 (Spastic Paraparesis With Amyotrophy, Cataracts And Gastroesophageal Reflux), Aldehyde Dehydrogenase 18 Family, Member A1, Delta-1-Pyrroline-5-Carboxylate Synthetase, Delta-1-Pyrroline-5-Carboxylate Synthase, Delta1-Pyrroline-5-Carboxlate Synthetase, sc104810, sc 104810
Symbol: ALDH18A1
Category: Polyclonal Antibodies
Research Use Only