ApoE rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES5847-50, ES5847-100
Citations, Manuals and MSDS Available upon request.
Background: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016],
Alternate Name: APOE; Apolipoprotein E; Apo-E
Source: Rabbit
Applications: WB; ELISA
Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Reactivity: Human; Rat; Mouse;
Immunogen: Synthesized peptide derived from the Internal region of human ApoE.
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 36kD
Human Gene ID: 348
Human SWISS Prot NO: P02649
Subcellular Location: Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner (PubMed:9488694). Lipidation induces the release from the extracellular matrix (PubMed:9488694).
Research Use Only