ARHGEF3 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A8490-20, A8490-100
Citations, Manuals and SDS Available upon request.
Background: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: GEF3; STA3; XPLN; ARHGEF3
GeneID: 50650
Swiss Prot: Q9NR81
Tested Applications: ELISA, WB
Reactivity: Human, Mouse
Calculated Molecular Weight: 60kDa
Observed Molecular Weight: 60kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 287-526 of human ARHGEF3 (NP_062455.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: MCF7, HepG2
Cellular Location: Cytoplasm
Keywords: 50650, ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3, rho guanine nucleotide exchange factor 3, 59.8 kDA protein, Rho guanine nucleotide exchange factor (GEF) 3, RhoGEF protein, exchange factor found in platelets and leukemic and neuronal tissues, Q9NR81, Rho Guanine Nucleotide Exchange Factor 3, Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues, Rho Guanine Nucleotide Exchange Factor (GEF) 3, RhoGEF Protein, 59.8 KDA Protein
Symbol: ARHGEF3
Category: Polyclonal Antibodies
Research Use Only