ARTN Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A7949-20, A7949-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.
Synonyms: ART; EVN; NBN; ENOVIN; ARTN
GeneID: 9048
Swiss-Prot: Q5T4W7
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 23kDa
Observed Molecular Weight: 28kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 122-220 of human ARTN (NP_476432.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cell Biology Developmental Biology, Growth factors, Neuroscience
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 22Rv1
Cellular Location: Secreted
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.