ATP7B Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A5676-20, A5676-100
Citations, Manuals and SDS Available upon request.
Background: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation.
Synonyms: WD; PWD; WC1; WND; ATP7B
GeneID: 540
Swiss-Prot: P35670
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 157kDa
Observed Molecular Weight: 157kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1251-1351 of human ATP7B (NP_001230111.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:1000 - 1:2000 | IHC-P: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Rat liver
Cellular Location: Cytoplasm, Golgi Apparatus, Golgi Apparatus Membrane, Mitochondrion, Multi-pass Membrane Protein, Multi-pass Membrane Protein, Trans-Golgi Network Membrane
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.