BEST1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-64917-60, E-AB-64917-120, E-AB-64917-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: BEST1
Target Synonym: BEST1; ARB; BEST; BMD; RP50; TU15B; VMD2
Research Areas: Cancer,Neuroscience
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: WB
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: O76090
Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Concentration: 1 mg/mL
Immunogen: Recombinant fusion protein of human BEST1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000
Calculated MW: 57kDa/67kDa/69kDa
Observed MW: 68kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only