NPY Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A3178-20, A3178-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.
Synonyms: PYY4; NPY
GeneID: 4852
Swiss-Prot: P01303
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 11kDa
Observed Molecular Weight: 11kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-97 of NPY (NP_000896.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, G protein signaling, G-Protein-Coupled Receptors (GPCR), Endocrine Metabolism, Neuroscience, Cardiovascular, Angiogenesis, Heart, Contractility, Hypertrophy
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: SH-SY5Y
Cellular Location: Secreted
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.