Caspase 10 (p23/17, Cleaved-Val220) Rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES17852-50, ES17852-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],
Alternate Name: Caspase-10 (CASP-10; EC 3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Source: Rabbit
Applications: WB; ELISA
Dilution: WB 1:500-2000, ELISA (peptide)1:5000-20000
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized peptide derived from human Caspase 10 (p23/17, Cleaved-Val220)
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 58+23kD
Human Gene ID: 843
Human SWISS Prot NO: Q92851
Subcellular Location: cytosol, CD95 death-inducing signaling complex, ripoptosome,
Research Use Only