GRK2 (Phospho-Ser685) Rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES8884-50, ES8884-100
Citations, Manuals and MSDS Available upon request.
Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
Alternate Name: Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Source: Rabbit
Applications: WB; ELISA
Dilution: WB 1:500-2000, ELISA 1:10000-20000
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized phospho derived from human GRK2 (Phospho-Ser685)
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): 80kD
Human Gene ID: 156
Human SWISS Prot NO: P25098
Subcellular Location: Cytoplasm. Cell membrane. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse.
Research Use Only