IGF1R (Phospho-Tyr1161) Rabbit pAb
Sizes: 50μL, 100μL
Catalogue Numbers: ES8878-50, ES8878-100
Citations, Manuals and MSDS Available upon request.
Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
Alternate Name: Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Source: Rabbit
Applications: WB; ELISA
Dilution: WB 1:500-2000, ELISA 1:10000-20000
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized phospho derived from human IGF1R (Phospho-Tyr1161)
Storage and Stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band (KD): pro: 155kD, recetor beta: 95kD
Human Gene ID: 3480
Human SWISS Prot NO: P08069
Subcellular Location: Cell membrane; Single-pass type I membrane protein.
Research Use Only