IntegrinAlpha 4 Polyclonal Antibody
Sizes: 20μL, 50μL, 100μL
Catalogue Numbers: BT-AP04574-20, BT-AP04574-50, BT-AP04574-100
Citations, Manuals and MSDS Available upon request.
Background: ITGA4 encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohnand#39;s disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.
Research Areas: Immunology
Target Protein: ITGA4
Applications: WB, IHC-p, ELISA
Reactivity: Human, Mouse, Rat
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
Full Product Name: Integrin alpha4 Antibody
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Storage: -20°C for 1 year
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Molecular Weight (Da): 115333
UniProt Accession: Human: P13612; Mouse: Q00651
Synonyms: ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d
GeneID: Human: 3676; Mouse: 16401
Research Use Only