SRGAP3 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-11600-60, E-AB-11600-120, E-AB-11600-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: SRGAP3
Target Synonym: ARHGAP 14; ARHGAP14; Gbi; ME GAP; MEGAP; Mental disorder associated GAP; Mental disorder-associated GAP; Rho GTPase activating protein 14; Rho GTPase-activating protein 14; SLIT ROBO Rho GTPase activating protein 3; SLIT-ROBO Rho GTPase-activating protein 3; srGAP 2; srGAP 3; srGAP2; srGAP3; SRGP 2; SRGP2; SRGP3; WAVE associated Rac GTPase activating protein; WAVE-associated Rac GTPase-activating protein; WRP
Research Areas: Neuroscience, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: O43295
Background: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Concentration: 0.6 mg/mL
Immunogen: Recombinant protein of human SRGAP3
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:25-1:100
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only