58K Golgi Protein Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90009-50, BS90009-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O95954(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, IHC FC
All Applications: WB:1:500-1:1,000
IHC:1:50-1:200
FC:1:50-1:100
Background: 58K protein antibodies are excellent for use as markers for the Golgi complex. The 58K protein has been identified as being FTCD, a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Defects in FTCD are the cause of glutamate formiminotransferase deficiency [also known as formiminoglutamicaciduria (FIGLU-uria)], an autosomal recessive disorder. Features of a severe phenotype include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay and no hematological abnormalities.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: 58K Golgi protein polyclonal antibody detects endogenous levels of 58K Golgi protein protein.
Bioworld Molecular Weight: 59 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-58K Golgi protein antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-58K Golgi protein antibody. Counter stained with hematoxylin.
Alternative Name: FTCD, LCHC1, FTCD, Formimidoyltetrahydrofolate cyclodeaminase, Formimidoyltransferase cyclodeaminase, Formiminotetrahydrofolate cyclodeaminase, Formiminotransferase cyclodeaminase, Formiminotransferase-cyclodeaminase, FTCD, FTCD, Glutamate formiminotransferase, Glutamate formyltransferase, LCHC 1, LCHC1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified