5T4 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90011-50, BS90011-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q13641(Human) Q9Z0L0(Mouse) Q5PQV5(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB IP
All Applications: WB:1:1,000-1:5,000
Background: TPBG (trophoblast glycoprotein), also known as 5T4, M6P1 or 5T4AG, is a 420 amino acid single-pass type I membrane protein expressed by all types of trophoblasts as early as 9 weeks of development. TPBG contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has seven potential N-glycosylation sites and seven leucine-rich repeats, which are located in two regions separated by a hydrophilic stretch. Suggested to be involved in cell adhesion, TPBG may also be associated with tumor growth and progression.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of 5T4 on MCF-7 cellsLysates using anti-5T4 antibody at 1/1,000 dilution.
Bioworld Molecular Weight: 72 kDa
Specificity: 5T4 polyclonal antibody detects endogenous levels of 5T4 protein.
Alternative Name: 5T4 oncotrophoblast glycoprotein, WAIF1, TPBG, 5T4, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, 5T4AG, AW495680, M6P1, TPBG, TPBG, Trophoblast glycoprotein,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified