AChRα7 Polyclonal Antibody
Catalogue Numbers: BS60391-50, BS60391-100
Sizes: 50µl, 100µl
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P36544/Q494W8
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:5000~1:1000
0
Background: Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChRα7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: AChRα7 polyclonal antibody detects endogenous levels of AChRα7 protein.
Extra Notes: Western blot (WB) analysis of AChRα7 pAb at 1:5000 dilution
Lane1:PC12 whole cell lysate(40ug)
Lane2:AML-12 whole cell lysate(40ug)
Lane3:HCT116 whole cell lysate(40ug)
Lane4:EC9706 whole cell lysate(40ug)
Lane5:SGC7901 whole cell lysate(40ug)
Lane6:A549 whole cell lysate(40ug)
Lane7:HEK293T whole cell lysate(40ug)
Bioworld Molecular Weight: ~ 56 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Neuronal acetylcholine receptor subunit alpha-7; CHRNA7; NACHRA7; CHRNA7-FAM7A fusion protein; CHRNA7-DR1; D-10; CHRFAM7A
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified