AF/LE Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12] - E-AB-F11310

AF/LE Purified Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

Sizes: 500μg, 1mg

Catalogue Numbers: E-AB-F11310-500, E-AB-F11310-1

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD279/PD-1

Target Synonym: PD-1, Programmed Death-1,

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Host: Rat

Species Reactivity: Mouse

Application: FCM,Block,Neut

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Rat IgG2a, κ

Clone No.: 29F.1A12

UNIProt ID: Q02242

Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F098330

Buffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Gene ID: 18566

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag

Research Use Only