AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4] - E-AB-F10180

AF/LE Purified Anti-Mouse CD54 Antibody [YN1/1.7.4]

Sizes: 500μg, 1mg

Catalogue Numbers: E-AB-F10180-500, E-AB-F10180-1

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD54

Target Synonym: Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1,

Conjugation: None (Purified antibody-Azide Free/Low endotoxin)

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Rat IgG2b, κ

Clone No.: YN1/1.7.4

UNIProt ID: P13597

Background: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F098430

Buffer: 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Gene ID: 15894

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag

Research Use Only