Anti-MERS-CoV Nucleocapsid Monoclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-V1281-50, E-AB-V1281-100
Citations, Manuals and MSDS Available upon request.
Target Synonym: coronavirus NP; coronavirus Nucleocapsid; coronavirus Nucleoprotein; cov np; ncov NP; novel coronavirus Nucleoprotein; NP; Nucleocapsid; Nucleoprotein
Conjugation: Unconjugated
Host: Mouse
Species Reactivity: MERS-CoV
Application: WB, ELISA
Isotype: IgG1
Clonality: Monoclonal
Clone No.: 10
Background: Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Concentration: 1mg/mL
Immunogen: Recombinant MERS-CoV Nucleoprotein / NP protein (His Tag)
Buffer: 0.2 μm filtered solution in PBS
Purification Method: Protein A Affinity
Dilution: WB 1:1000-1:5000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only