APC Anti-Mouse CD279/PD-1 Antibody [29F.1A12] - E-AB-F1131UE

APC Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

Size: 100μg

Catalogue Number: E-AB-F1131UE-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD279/PD-1

Target Synonym: PD-1, Programmed Death-1,

Conjugation: APC

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume].

Isotype: Rat IgG2a, κ

Clone No.: 29F.1A12

UNIProt ID: Q02242

Background: CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Concentration: 0.2 mg/mL

Control Catalogue Number: E-AB-F09833E

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 18566

Storage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.

Shipping: Ice bag