APC Anti-Mouse CD51 Antibody [RMV-7] - E-AB-F1235E

APC Anti-Mouse CD51 Antibody [RMV-7]

Sizes: 100 Tests, 100 Tests×2

Catalogue Numbers: E-AB-F1235E-100, E-AB-F1235E-100×2

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD51

Target Synonym: Integrin alpha-V, αV integrin, Vitronectin Receptor, Integrin αV chain, ITGAV,

Conjugation: APC

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Isotype: Rat IgG1, κ

Clone No.: RMV-7

UNIProt ID: P43406

Background: CD51 is a 140 kD protein, also known as αV-integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6, these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Concentration: 5 μL/Test

Control Catalogue Number: E-AB-F09822E

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Gene ID: 16410

Storage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.

Shipping: Ice bag

Research Use Only