APC Anti-Mouse Foxp3 Antibody [3G3] - E-AB-F1238E

APC Anti-Mouse Foxp3 Antibody [3G3]

Sizes: 50 Tests, 100 Tests, 100 Tests×2

Catalogue Numbers: E-AB-F1238E-50, E-AB-F1238E-100, E-AB-F1238E-100×2

Citations, Manuals and MSDS Available upon request.

Abbreviation: Foxp3

Target Synonym: Forkhead box protein P3, IPEX, JM2, Foxp3,

Conjugation: APC

Host: Mouse

Species Reactivity: Mouse

Application: ICFCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Isotype: Mouse IgG1, κ

Clone No.: 3G3

UNIProt ID: Q99JB6

Background: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25-cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.

Concentration: 5 μL/Test

Control Catalogue Number: E-AB-F09792E

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 5, 094, 320, 371, 317, 380

Storage: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Shipping: Ice bag

Research Use Only