APC Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-67493-60, E-AB-67493-120, E-AB-67493-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: APC
Target Synonym: APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
Research Areas: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: IHC, IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P25054
Background: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human APC (NP_000029.2).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200 IF 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only