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ITPR2 Polyclonal Antibody - E-AB-92150

ITPR2 Polyclonal Antibody - E-AB-92150

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ITPR2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-92150-60, E-AB-92150-120, E-AB-92150-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ITPR2

Target Synonym: ANHD; CFAP48; INSP3R2; IP3R2; ITPR2

Research Areas: Cancer, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q14571

Background: The protein encoded by this gene belongs to the inositol 1, 4, 5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human ITPR2

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only