JNK1/2/3 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-93242-60, E-AB-93242-120, E-AB-93242-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: JNK1/2/3
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC, IF, IP
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P45983/P45984/P53779
Background: JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1, JNK2, and JNK3
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human JNK1/2/3
Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200, IP 1:50-1:100
Calculated MW: 35kDa/44kDa/48kDa/27kDa/52kDa
Observed MW: 46kDa/54kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only