LOXL1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-63293-60, E-AB-63293-120, E-AB-63293-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: LOXL1
Target Synonym: LOXL1; LOL; LOXL
Research Areas: Cell biology,Metabolism,Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse
Application: IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q08397
Background: This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome.
Concentration: 1 mg/mL
Immunogen: Recombinant fusion protein of human LOXL1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IF 1:50-1:200
Calculated MW: 63kDa
Observed MW: 80kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only