MBTPS2 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-52057-60, E-AB-52057-120, E-AB-52057-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: MBTPS2
Target Synonym: BRESEK; Endopeptidase S2P; IFAP; KFSDX; MBTP2; MBTPS2; Membrane bound transcription factor site 2 protease; membrane-bound transcription factor peptidase; site 2; membrane-bound transcription factor protease; site 2; Membrane-bound transcription factor site-2 protease; S2P; S2P endopeptidase; Site 2 protease; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease
Research Areas: Cell Biology, Cardiovascular, Metabolism, Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: WB, IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: O43462
Background: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
Concentration: 0.9 mg/mL
Immunogen: Synthetic peptide of human MBTPS2
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: WB 1:500-1:2000, IHC 1:10-1:50, ELISA 1:5000-1:10000
Calculated MW: 57 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only