MMP2 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-65806-60, E-AB-65806-120, E-AB-65806-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: MMP2
Target Synonym: CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1; MMP2
Research Areas: Cancer, Cell Biology, Cardiovascular, Metabolism
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P08253
Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human MMP2 (NP_004521.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IF 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only