MYC Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-63525-60, E-AB-63525-120, E-AB-63525-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: MYC
Target Synonym: MRTL; MYCC; bHLHe39; c-Myc; MYC
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Stem Cells
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse, Rat
Application: IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P01106
Background: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human MYC (NP_002458.2).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: IHC 1:50-1:100
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only