MYSM1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-12793-60, E-AB-12793-120, E-AB-12793-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: MYSM1
Target Synonym: 2A-DUB; 2ADUB; Histone H2A deubiquitinase; Histone H2A deubiquitinase MYSM1; KIAA1915; Myb like SWIRM and MPN domains 1; Myb like; SWIRM and MPN domain containing protein; Myb like; SWIRM and MPN domains 1; Myb-like; Myb-like; SWIRM and MPN domains 1; MYSM 1; mysm1; MYSM1 Myb-like; SWIRM and MPN domains 1; MYSM1; RP4-592A1.1; SWIRM and MPN domain-containing protein 1
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q5VVJ2
Background: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones
Concentration: 0.5 mg/mL
Immunogen: Synthetic peptide of human MYSM1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:50-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only