NF2 / Merlin Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: E-AB-40642-50, E-AB-40642-100
Citations, Manuals and MSDS Available upon request.
Abbreviation: NF2
Target Synonym: ACN; BANF; Merlin; Neurofibromin 2; neurofibromin 2 (merlin); NF2; SCH; Schwannomerlin; Schwannomin
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P35240
Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Concentration: 2.2mg/ml
Immunogen: Recombinant Human NF2 protein expressed by E.coli.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Purification Method: Antigen Affinity Purification
Dilution: WB 1:500-1:1000
Calculated MW: 70 kDa
Observed MW: 66-70 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only