NGEF Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-18859-60, E-AB-18859-120, E-AB-18859-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: NGEF
Target Synonym: ARHGEF27; Eph receptor-interacting exchange protein; Eph-interacting exchange protein; EPHEXIN; Ephexin-1; Guanine nucleotide exchange factor; neuronal; Neuronal guanine nucleotide exchange factor; Ngef; NGEF
Research Areas: Neuroscience, Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q8N5V2
Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Concentration: 0.6 mg/mL
Immunogen: Fusion protein of human NGEF
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only