NPM1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-40477-60, E-AB-40477-120, E-AB-40477-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: NPM1
Target Synonym: B23; MGC104254; NO38; NPM; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; nucleophosmin nucleoplasmin family member 1; Nucleophosmin/nucleoplasmin family member 1; Numatrin
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Application: WB, IHC
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q61937
Background: Nucleophosmin (NPM1, B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.
Concentration: 1mg/mL
Immunogen: Recombinant Mouse Nucleophosmin protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Purification Method: Antigen Affinity Purification
Dilution: WB 1:10000-1:20000 IHC 1:200-1:500
Calculated MW: 32 kDa
Observed MW: 37 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only