NRG1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-16491-60, E-AB-16491-120, E-AB-16491-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: NRG1
Target Synonym: Acetylcholine receptor-inducing activity; Acetylcholine receptor-inducing activity; CHICK; homolog of; ARIA; Breast cancer cell differentiation factor p45; GGF; GGF2; Glial growth factor; Heregulin; heregulin; alpha (45kD; ERBB2 p185-activator); HGL; HRG; HRG1; HRGA; MST131; NDF; Neu differentiation factor; Neuregulin 1; neuregulin 1 type IV beta 1a; neuregulin 1 type IV beta 3; Neuregulin-1; NRG 1; nrg1; NRG1-IT2; NRG1; OTTHUMP00000225398; OTTHUMP00000225419; OTTHUMP00000225420; OTTHUMP00000225421; OTTHUMP00000225422; OTTHUMP00000225477; OTTHUMP00000225545; OTTHUMP00000230603; OTTHUMP00000230605; pro-neuregulin-1; membrane-bound isoform; Pro-NRG1; ProNRG1; Sensory and motor neuron-derived factor; SMDF
Research Areas: Cancer, Neuroscience, Signal transduction
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Mouse
Application: WB, IHC, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q02297
Background: The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
Concentration: 0.6 mg/mL
Immunogen: Synthetic peptide of human NRG1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:50-1:200
Calculated MW: 70kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only