p16 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-40264-60, E-AB-40264-120, E-AB-40264-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: p16
Target Synonym: CCM2; CDK4 inhibitor p16 INK4; CDK4I; CDKN2; CDKN2A; Cell cycle negative regulator beta; CMM2; Cyclin dependent kinase 4 inhibitor A; Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4); Cyclin Dependent Kinase Inhibitor 2A
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat
Application: IHC, IF
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q9R0Z3
Background: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Concentration: 0.82 mg/mL
Immunogen: Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification Method: Antigen Affinity Purification
Dilution: IHC 1:50-1:200 IF 1:100-1:200
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only