p53 DINP1 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-92850-60, E-AB-92850-120, E-AB-92850-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: p53 DINP1
Target Synonym: TP53INP1; SIP; TP53DINP1; TP53INP1A; TP53INP1B; Teap; p53DINP1
Research Areas: Cancer, Cell Biology
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Mouse
Application: WB
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q96A56
Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human p53 DINP1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000
Calculated MW: 18kDa/27kDa
Observed MW: 32kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only