PFKFB3 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-53523-60, E-AB-53523-120, E-AB-53523-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: PFKFB3
Target Synonym: Renal Carcinoma Antigen NY-REN-56; PFK/FBPase 3; IPFK2; PFK2
Research Areas: Cardiovascular,Signal Transduction,Neuroscience,Cancer,Metabolism
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Human, Rat
Application: WB, ELISA
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: Q16875
Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP), and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Concentration: 0.5 mg/mL
Immunogen: Synthetic peptide of human PFKFB3
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method: Antigen affinity purification
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000
Calculated MW: 60 kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only