Proteinase 3/PR3 Polyclonal Antibody
Sizes: 60μL, 120μL, 200μL
Catalogue Numbers: E-AB-91805-60, E-AB-91805-120, E-AB-91805-200
Citations, Manuals and MSDS Available upon request.
Abbreviation: Proteinase 3/PR3
Target Synonym: ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; PRTN3
Conjugation: Unconjugated
Host: Rabbit
Species Reactivity: Rat
Application: WB
Isotype: IgG
Clonality: Polyclonal
UNIProt ID: P24158
Background: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro. By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human Proteinase 3/PR3
Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000
Observed MW: 25kDa
Storage: -20°C/One year. Avoid freeze / thaw cycles.
Shipping: Ice bag
Research Use Only